2‐Hydrazinopyridine Inhibition of Lysyl oxidase‐like 2

LOXL2 (lysyl oxidase-like 2)

The LOXL2 gene is located on chromosome 8p21.2p21.3 (Jourdan-Le Saux et al., 1998). It is composed of fourteen exons and thirteen introns, distributed through approximately 107 kb of genomic DNA (Fong et al., 2007). Two transcripts of sizes 3.6 kb and 4.9 kb have been reported, with the smaller transcript much more abundant and resulting from three possible termination sites located 690 bp, 740...

Specific Inhibition of the Synthesis of Human Lysyl-tRNA Synthetase

Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer

Lysyl oxidase (LOX) and LOX-like (LOXL) enzymes are key players in extracellular matrix deposition and maturation. LOX promote tumour progression and metastasis, but it may also have tumour-inhibitory effects. Here we show that orthotopic implantation of rat prostate AT-1 tumour cells increased LOX and LOXLs mRNA expressions in the tumour and in the surrounding non-malignant prostate tissue. In...

Inhibition of proteases by alpha 2-macroglobulin. The role of lysyl amino groups of trypsin in covalent complex formation.

The lysyl amino groups of bovine trypsin were covalently modified by acetylation, succinylation, or reductive methylation. The enzymatically active derivatives were still capable of reaction with alpha 2-macroglobulin (alpha 2M), although to a lesser extent than native enzyme. The resulting enzyme-alpha 2M complexes, however, were much more susceptible to dissociation by sodium dodecyl sulfate ...

Inhibition of Mild Steel Corrosion in Sulfuric Acid Solution by 2-Hydropyrimidine-2-Thione Derivative

The corrosion inhibition potential and efficacy of 2-hydropyrimidine-2-thione derivative on mildsteel in 0.5 M sulfuric acid solution was investigated using electrochemical polarization and FTIRspectroscopic techniques. In addition, docking studies were carried out as theoretical investigationof adsorption inhibitor on iron surface. The results of polarization studies indicate...